rubidium 82 based

Frontiers | Story of Rubidium-82 and Advantages …

Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF), clinical studies were …

Rubidium 82

Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a …

Study updates dose estimates for rubidium-82 cardiac PET

Rubidium-82 is increasingly being used for cardiac PET imaging, but radiation dose estimates for the exams are based on old -- and conflicting -- data. Researchers from Johns Hopkins University offer updated dose estimates for rubidium-82 procedures in a study published in the October issue of the Journal of Nuclear Medicine.

Rubidium-82 generator yield and efficiency for PET …

Introduction. Rubidium-82 (82 Rb) is a widely used positron emission tomography (PET) tracer with a short half-life of ~ 75 seconds.1 Stress perfusion imaging with 82 Rb is used widely in cardiac PET centers for the assessment of known or suspected coronary artery disease.2 The short half-life of 82 Rb allows rapid sequential rest and …

Estimation of renal perfusion based on measurement of Rubidium-82 …

We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/ computed tomography (PET/CT) and rubidium-82 (⁸²Rb) using the abdominal aorta as input function in a ...

Federal Register :: Rubidium-82 Generators, Emerging …

On July 3, 2023, the U.S. Nuclear Regulatory Commission (NRC) solicited comments on the regulatory basis for the planned rulemaking on "Rubidium-82 Generators, Emerging Technologies, and Other Medical Use of Byproduct Material." The public comment period was originally scheduled to close on October 31, 2023.

Rubidium-82 Generators, Emerging Technologies, and …

The regulatory basis, titled "Rubidium-82 Generators, Emerging Technologies, and Other Medical Use of Byproduct Material—Regulatory Basis," can be obtained at ADAMS Accession No. ML23122A356. ... The analyses are based on the NRC's preliminary assessment and estimates, and the NRC will conduct a more detailed …

Generator-produced rubidium-82 positron

Rubidium-82 (82 Rb) is a generator-produced PET myocardial perfusion tracer and has been widely used in North America in clinical practice. 82 Rb PET has recently become available in some cardiovascular centers in …

Myocardial Rubidium-82 Tissue Kinetics Assessed by …

Background Recent reports have demonstrated the clinical use of rubidium-82 chloride (Rb-82) in combination with positron emission tomography (PET) not only as a tracer of myocardial blood flow but also …

Rubidium Rb 82 (Intravenous Route) Precautions

Precautions. Drug information provided by: Merative, Micromedex ®. It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. You might receive a medicine to make your ...

CardioGen-82 | Bracco

CardioGen-82. The Bracco Group is an international group of highly specialized companies. We are an active part of the healthcare sector, and a global leader in diagnostic imaging. CardioGen-82 est un générateur radiopharmaceutique de rubidium-82 (82Rb) contenant du strontium-82 (82Sr) qui permet d'obtenir par élution des solutions ...

New effective dose estimates for Rubidium-82 based on …

1429 Objectives Published radiation dose estimates for Rubidium-82 vary widely, and no comprehensive study in man has yet been conducted. With the increasing use of Rb-82 PET for myocardial perfusion imaging, improved dosimetry information is needed for accurate risk assessment. The purpose of this study was to measure Rb-82 internal …

RUBY-FILL® (Rubidium Rb 82 Generator) and Elution …

The RUBY-FILL® Rubidium Rb 82 Generator contains accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride used for Cardiac Positron Emission Tomography (PET), a non-invasive imaging procedure of the myocardium, to evaluate …

Cardiogen-82 (rubidium Rb 82 generator): Side Effects, Uses

Dosage Forms And Strengths. CardioGen-82 is a closed system used to produce rubidium Rb 82 chloride injection for intravenous use. CardioGen-82 consists of strontium Sr-82 adsorbed on a hydrous stannic oxide column with an activity of 90-150 millicuries Sr-82 at calibration time.

Cardiac PET/CT with Rb-82: optimization of image …

Background. Hybrid cardiac positron emission tomography/computed tomography (PET/CT) with 82 rubidium (82 Rb) is a useful clinical tool for the diagnosis of unknown or suspected coronary arterial disease (CAD) and microvascular disease, improving the understanding of the pathophysiology of disease processes thus directly …

Comparison of maximal Rubidium-82 activities for …

Background PET-based myocardial blood flow (MBF) quantification can be inaccurate when using high tracer activities. Our aim was to derive the maximal Rubidium-82 activity for MBF assessment using a new digital PET system and compare the results with conventional analog systems. Methods 1.8 GBq Rubidium-82 was injected into the …

CardioGen-82 | Bracco

Cardiogen-82 is a radionuclide generator of rubidium-82 (Rb-82) containing strontium-82 (Sr-82) adsorbed on stannic oxide in a chromatography column. It provides a means of obtaining, via elution, a sterile, non-pyrogenic injectable solution of …

Draft Regulatory Basis Document for the Rulemaking to …

Rubidium-82 Generators and Emerging Medical Technologies," dated January 13, 2022 ... based requirements for existing EMTs based on operating experience,and (3) revise other outdated, prescriptive requirements with risk-informed, …

Reliability of rubidium-82 PET/CT for renal perfusion …

The latter based on the indication that 82 Rb is primarily present in the plasma during the short duration of the dynamic PET/CT study [37, 38], as well as the observation that our previously measured 82 Rb clearance values (766 ± 114 ml/min/1.73 m 2) are similar to historically published values for ERPF [26, 39, 40].

Generator-produced rubidium-82 positron emission

Rubidium-82 (82 Rb) is a PET myocardial perfusion tracer that is produced with a strontium-82 (82 Sr) ... Net extraction data of 82 Rb based on Katoh et al. [44] and Lortie et al. [14]. Among PET perfusion tracers, 82 Rb has the shortest physical half-life …

Rubidium 82

Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the …

Myocardial perfusion scintigraphy using rubidium-82 …

The 'Evidence based indications for the use of PET CT in the United Kingdom', recommend the use of both 13 N-ammonia and 82 Rb MPS as alternatives to SPECT. 34 Against this 82 Rb MPS is currently available in only two centres: at our institution and at University College Hospital, London.

Comparison of the prognostic value of impaired stress

Background The most reliable quantitative variable on Rubidium-82 (82Rb) cardiac PET/CT for predicting major adverse cardiovascular events (MACE) has not been characterized with low-dose silicon photomultipliers (SiPM) technology, which allows halving injected activity and radiation dose delivering less than 1.0 mSv in a 70-kg individual. …

Regulatory Basis for 10 CFR Part 35 Rulemaking on …

measurement for strontium- 82/rubidium-82 generators. – New subpart for microspheres (i.e., "Microsource Manual Brachytherapy'). – Requiring device-specific training for some generators and EMTs. – Specific device components → → → Functional elements of the technologies. • Note that this rulemaking would not establish ...

Estimation of renal perfusion based on measurement of rubidium-82 …

Conclusion. Measurement of renal perfusion based on PET/CT and 82 Rb using AA as input function in a 1-tissue compartment model is feasible in a single FOV. Based on previous studies showing 82 Rb to be primarily present in plasma, the measured K 1 clearance values are most likely representative of effective renal plasma flow (ERPF) …

Rubidium 82

Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a generator life of 6 to 8 weeks. The short T 1/2 of 82 Rb (76 seconds) allows repeated and sequential perfusion studies but requires rapid image acquisition shortly after ...

RUBY-FILL- rubidium rb 82 injection, solution Jubilant …

The recommended weight-based dose of rubidium Rb 82 chloride to be administered per rest or stress component of a PET myocardial perfusion imaging (MPI) procedure is between 10-30 Megabecquerels (MBq)/kg [0.27-0.81 millicuries (mCi)/kg]. Do not exceed a single dose of 2220 MBq (60 mCi).

A systemic review of rubidium-82 PET contrasted …

In this regard, the purpose of this study is to determine whether 82-Rubidium-PET can offer extra value over 99mTc-sestamibi SPECT in imaging CAD by, …

CARDIOGEN-82- rubidium chloride rb-82 injection, solution

CardioGen-82 ® (rubidium Rb 82 generator), used to produce rubidium Rb 82 chloride injection, consists of Sr 82 adsorbed on a hydrous stannic oxide column with an activity of 3,330 MBq to 5,550 MBq (90 millicuries to 150 millicuries) Sr 82 at calibration time. A lead shield surrounded by a labeled plastic container encases the generator.

New effective dose estimates for Rubidium-82 based …

Abstract. 1429. Objectives Published radiation dose estimates for Rubidium-82 vary widely, and no comprehensive study in man has yet been conducted. With the increasing use of …